| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine--tRNA ligase |
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| Ligand | BDBM95739 |
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| Substrate/Competitor | n/a |
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| IC50 | 1472±n/a nM |
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| Citation |  PubChem, PC Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) PubChem Bioassay(2013)[AID] |
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| More Info.: | Get all data from this article |
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| Methionine--tRNA ligase |
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| Name: | Methionine--tRNA ligase |
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| Synonyms: | methionyl-tRNA synthetase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86905.45 |
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| Organism: | Trypanosoma brucei brucei strain 927/4 GUTat10.1 |
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| Description: | gi_71746704 |
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| Residue: | 773 |
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| Sequence: | MALKLLSEKANSQALKVLLCSYYVKRPVEVSLSGAYATPILHHPAFKQPIIAPNEMARVI
LFYSVEPTSNNGGAADSSNGDGTASPVAGLTNLTLEHETWLEWEATTFTRAVHPLYTQRR
QTAESLAVFSYLDKKISENDDRCVYSPAVEGKGAADPTDAVSTFFIDCIVWCAVLPALCE
SGVLRDSEKQQLPHLVKWFNTFQKEQKTLIDNAFENLSVQEAADFLRCPRVYKVSAKVEK
VFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVFALTGTDEHGQKVAEAAKQK
QVSPYDFTAAVAGEFKKCFEQMDYSIDYFIRTTNEQHKAVVKELWTKLEQKGDIYLGRYE
GWYSISDESFLTPQNITDGVDKDGNPCKVSLESGHVVTWVSEENYMFRLSAFRERLLEWY
HANPGCIVPEFRRREVIRAVEKGLPDLSVSRKKETLHNWAIPVPGNPDHCVYVWLDALTN
YLTGSRLRVDESGKEVSLADDFSELERFPADVHVIGKDILKFHAIYWPAFLLSAGLPLPK
KIVAHGWWTKDRKKISKSLGNVFDPVEKAEEFGYDALKYFLLRESGFSDDGDYSDKNMIA
RLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESLIQLIKDLPGTADHYYLIPD
IQKAIIAVFDVLRAINAYVTDMAPWKLVKTDPERLRTVLYITLEGVRVTTLLLSPILPRK
SVVIFDMLGVPEVHRKGIENFEFGAVPPGTRLGPAVEGEVLFSKRSTENTKST
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| BDBM95739 |
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| n/a |
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| Name | BDBM95739 |
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| Synonyms: | MLS000679757 | N-(3-chloranyl-4-fluoranyl-phenyl)-4-oxidanylidene-3,10-dihydro-2H-pyrimido[1,2-a]benzimidazole-2-carboxamide | N-(3-chloro-4-fluoro-phenyl)-4-keto-3,10-dihydro-2H-pyrimido[1,2-a]benzimidazole-2-carboxamide | N-(3-chloro-4-fluorophenyl)-4-oxo-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole-2-carboxamide | N-(3-chloro-4-fluorophenyl)-4-oxo-3,10-dihydro-2H-pyrimido[1,2-a]benzimidazole-2-carboxamide | SMR000296598 | cid_5741663 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12ClFN4O2 |
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| Mol. Mass. | 358.754 |
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| SMILES | Fc1ccc(NC(=O)C2CC(=O)n3c(N2)nc2ccccc32)cc1Cl |
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| Structure | 
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