| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Methionine--tRNA ligase |
|---|
| Ligand | BDBM95765 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 498.14±n/a nM |
|---|
| Citation |  PubChem, PC Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) PubChem Bioassay(2013)[AID] |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Methionine--tRNA ligase |
|---|
| Name: | Methionine--tRNA ligase |
|---|
| Synonyms: | methionyl-tRNA synthetase |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 86905.45 |
|---|
| Organism: | Trypanosoma brucei brucei strain 927/4 GUTat10.1 |
|---|
| Description: | gi_71746704 |
|---|
| Residue: | 773 |
|---|
| Sequence: | MALKLLSEKANSQALKVLLCSYYVKRPVEVSLSGAYATPILHHPAFKQPIIAPNEMARVI
LFYSVEPTSNNGGAADSSNGDGTASPVAGLTNLTLEHETWLEWEATTFTRAVHPLYTQRR
QTAESLAVFSYLDKKISENDDRCVYSPAVEGKGAADPTDAVSTFFIDCIVWCAVLPALCE
SGVLRDSEKQQLPHLVKWFNTFQKEQKTLIDNAFENLSVQEAADFLRCPRVYKVSAKVEK
VFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVFALTGTDEHGQKVAEAAKQK
QVSPYDFTAAVAGEFKKCFEQMDYSIDYFIRTTNEQHKAVVKELWTKLEQKGDIYLGRYE
GWYSISDESFLTPQNITDGVDKDGNPCKVSLESGHVVTWVSEENYMFRLSAFRERLLEWY
HANPGCIVPEFRRREVIRAVEKGLPDLSVSRKKETLHNWAIPVPGNPDHCVYVWLDALTN
YLTGSRLRVDESGKEVSLADDFSELERFPADVHVIGKDILKFHAIYWPAFLLSAGLPLPK
KIVAHGWWTKDRKKISKSLGNVFDPVEKAEEFGYDALKYFLLRESGFSDDGDYSDKNMIA
RLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESLIQLIKDLPGTADHYYLIPD
IQKAIIAVFDVLRAINAYVTDMAPWKLVKTDPERLRTVLYITLEGVRVTTLLLSPILPRK
SVVIFDMLGVPEVHRKGIENFEFGAVPPGTRLGPAVEGEVLFSKRSTENTKST
|
|
|
|---|
| BDBM95765 |
|---|
| n/a |
|---|
| Name | BDBM95765 |
|---|
| Synonyms: | (2S,4S)-N-(1H-benzimidazol-2-ylmethyl)-4-(4-bromophenyl)-2-(4-methylolbenzyl)oxy-3,4-dihydro-2H-pyran-6-carboxamide | (2S,4S)-N-(1H-benzimidazol-2-ylmethyl)-4-(4-bromophenyl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-carboxamide | MLS000834578 | SMR000442102 | cid_16197146 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H26BrN3O4 |
|---|
| Mol. Mass. | 548.428 |
|---|
| SMILES | OCc1ccc(CO[C@@H]2C[C@@H](C=C(O2)C(=O)NCc2nc3ccccc3[nH]2)c2ccc(Br)cc2)cc1 |c:11| |
|---|
| Structure | 
|
|---|
Search and Browse
