| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Ligand | BDBM36539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Thermal Shift Assay |
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| pH | 7.5±0 |
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| Ki | 0.12±0.01 nM |
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| Citation |  Chang, A; Schiebel, J; Yu, W; Bommineni, GR; Pan, P; Baxter, MV; Khanna, A; Sotriffer, CA; Kisker, C; Tonge, PJ Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme-Product Complex. Biochemistry52:4217-28 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Synonyms: | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase |
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| Type: | Enzyme |
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| Mol. Mass.: | 27989.00 |
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| Organism: | Staphylococcus aureus |
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| Description: | Q6GI75 |
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| Residue: | 256 |
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| Sequence: | MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
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| BDBM36539 |
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| n/a |
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| Name | BDBM36539 |
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| Synonyms: | 5-chloro-2-phenoxylphenol | PT52 | US10071965, Compound PT52 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9ClO2 |
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| Mol. Mass. | 220.652 |
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| SMILES | Oc1cc(Cl)ccc1Oc1ccccc1 |
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| Structure | 
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