| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
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| Ligand | BDBM280023 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assays for IDH1m (R132H or R132C) Inhibitors |
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| pH | 6.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | <50±n/a nM |
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| Comments | extracted |
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| Citation |  Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D Therapeutically active compounds and their methods of use US Patent US10028961 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
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| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
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| Synonyms: | IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46607.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75874[R132C] |
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| Residue: | 414 |
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| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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| BDBM280023 |
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| n/a |
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| Name | BDBM280023 |
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| Synonyms: | US10028961, Compound 176 | US10172864, Compound 176 | US10946023, Compound 176 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22F7N7 |
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| Mol. Mass. | 481.4137 |
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| SMILES | FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1 |
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| Structure | 
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