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TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q]
LigandBDBM280034
Substrate/Competitorn/a
Meas. Tech.In Vitro Assays for IDH2m R140Q Inhibitors
pH7.5±n/a
Temperature298.15±n/a K
IC50<50±n/a nM
Commentsextracted
Citation Konteatis, ZDPopovici-Muller, JTravins, JMZahler, RCai, ZZhou, D Therapeutically active compounds and their methods of use US Patent US10028961 Publication Date 7/24/2018
More Info.:Get all data from this article,  Assay Method
 
Isocitrate dehydrogenase [NADP], mitochondrial [R140Q]
Name:Isocitrate dehydrogenase [NADP], mitochondrial [R140Q]
Synonyms:IDH2 | IDH2(R140Q) | IDHP_HUMAN | idh2 r140q
Type:Enzyme Catalytic Domain
Mol. Mass.:50823.17
Organism:Homo sapiens (Human)
Description:P48735 (R140Q)
Residue:452
Sequence:
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIGNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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  Blast E-value cutoff:
BDBM280034
n/a
NameBDBM280034
Synonyms:US10028961, Compound 187 | US10172864, Compound 187 | US10946023, Compound 187
TypeSmall organic molecule
Emp. Form.C18H18F6N6
Mol. Mass.432.3661
SMILESCC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
Structure
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