| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [17-535] |
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| Ligand | BDBM97665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.2±0 |
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| Ki | 59±0.0 nM |
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| Citation |  Lampe, JW; Watson, PS; Slade, DJ Bridged bicyclic RHO kinase inhibitor compounds, composition and use US Patent US8476295 Publication Date 7/2/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Rho-associated protein kinase 1 [17-535] |
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| Name: | Rho-associated protein kinase 1 [17-535] |
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| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho GDP-dissociation inhibitor 1 | Rho Kinase 1 | Rho-associated protein kinase 1 (ROCK1) |
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| Type: | Protien |
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| Mol. Mass.: | 60345.48 |
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| Organism: | Homo Sapiens (Human) |
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| Description: | aa 17-535 |
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| Residue: | 519 |
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| Sequence: | LLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY
EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWV
VQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIH
RDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG
RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAF
LTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKG
EEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE
EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRIN
EYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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|
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| BDBM97665 |
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| n/a |
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| Name | BDBM97665 |
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| Synonyms: | US8476295, 1.1.03 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N4O2 |
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| Mol. Mass. | 392.494 |
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| SMILES | OCCOc1cccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)c1 |THB:18:16:12.13:10| |
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| Structure | 
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