| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [17-535] |
|---|
| Ligand | BDBM97666 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.2±0 |
|---|
| Ki | 35±0.0 nM |
|---|
| Citation |  Lampe, JW; Watson, PS; Slade, DJ Bridged bicyclic RHO kinase inhibitor compounds, composition and use US Patent US8476295 Publication Date 7/2/2013 |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Rho-associated protein kinase 1 [17-535] |
|---|
| Name: | Rho-associated protein kinase 1 [17-535] |
|---|
| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho GDP-dissociation inhibitor 1 | Rho Kinase 1 | Rho-associated protein kinase 1 (ROCK1) |
|---|
| Type: | Protien |
|---|
| Mol. Mass.: | 60345.48 |
|---|
| Organism: | Homo Sapiens (Human) |
|---|
| Description: | aa 17-535 |
|---|
| Residue: | 519 |
|---|
| Sequence: | LLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY
EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWV
VQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIH
RDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG
RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAF
LTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKG
EEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE
EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRIN
EYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
|
|
|
|---|
| BDBM97666 |
|---|
| n/a |
|---|
| Name | BDBM97666 |
|---|
| Synonyms: | US8476295, 1.1.04 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H30N4O2 |
|---|
| Mol. Mass. | 406.5206 |
|---|
| SMILES | Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1OCCO |THB:14:12:8.9:6| |
|---|
| Structure | 
|
|---|
Search and Browse
