| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 2 [11-552] |
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| Ligand | BDBM97666 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.2±0 |
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| Ki | 10±0.0 nM |
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| Citation |  Lampe, JW; Watson, PS; Slade, DJ Bridged bicyclic RHO kinase inhibitor compounds, composition and use US Patent US8476295 Publication Date 7/2/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Rho-associated protein kinase 2 [11-552] |
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| Name: | Rho-associated protein kinase 2 [11-552] |
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| Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho kinase 2 (ROCKII) | Rho-associated protein kinase 2 |
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| Type: | Protein |
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| Mol. Mass.: | 62268.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Chemicon #14-451 |
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| Residue: | 542 |
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| Sequence: | PGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDN
FLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIK
RSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKW
AKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTA
VGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHK
NSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAP
VVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRE
TDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITL
RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS
QI
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|
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| BDBM97666 |
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| n/a |
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| Name | BDBM97666 |
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| Synonyms: | US8476295, 1.1.04 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N4O2 |
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| Mol. Mass. | 406.5206 |
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| SMILES | Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1OCCO |THB:14:12:8.9:6| |
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| Structure | 
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