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TargetMacrophage colony-stimulating factor 1 (CSF-1)
LigandBDBM97735
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Competition Immunoassay
pH7.5±0
IC50 3± 0 nM
Citation Illig CRBallentine SKChen JDesJarlais RLMeegalla SKWall MWilson K Inhibitors of c-fms kinase US Patent  US8481564 Publication Date 7/9/2013
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Macrophage colony-stimulating factor 1 (CSF-1)
Name:Macrophage colony-stimulating factor 1 (CSF-1)
Synonyms:n/a
Type:Protein
Mol. Mass.:60631.84
Organism:Mus musculus (Mouse)
Description:P07141
Residue:552
Sequence:
MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQME
TSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLN
SCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSS
RDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELP
LRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGT
NWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFPKSTEDQKPVDIT
DRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQL
LLPKSHSWGIVLPLGELEGKRSTRDRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVE
QHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSHRDPQTLDSSVGRPEDSSL
TQDEDRQVELPV
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  Blast E-value cutoff:
BDBM97735
n/a
NameBDBM97735
Synonyms:US8481564, 12
TypeSmall organic molecule
Emp. Form.C22H22N8O
Mol. Mass.414.4631
SMILESO=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(NC1)=NC#N)c1nc(c[nH]1)C#N |t:10,(6.88,1.32,;5.55,.55,;4.22,1.32,;2.88,.55,;2.88,-.99,;1.55,-1.76,;.22,-.99,;.22,.55,;1.55,1.32,;1.55,2.86,;2.88,3.63,;2.88,5.17,;1.55,5.94,;.22,5.17,;.22,3.63,;-1.12,-1.76,;-1.12,-3.3,;-2.45,-4.07,;-3.78,-3.3,;-3.78,-1.76,;-2.45,-.99,;-5.12,-4.07,;-6.45,-3.3,;-7.79,-2.53,;6.32,-.78,;5.42,-2.03,;6.32,-3.27,;7.79,-2.8,;7.79,-1.26,;5.55,-4.61,;4.78,-5.94,)|
Structure
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