Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMacrophage colony-stimulating factor 1 (CSF-1)
LigandBDBM97736
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Competition Immunoassay
pH7.5±0
IC50 2± 0 nM
Citation Illig CRBallentine SKChen JDesJarlais RLMeegalla SKWall MWilson K Inhibitors of c-fms kinase US Patent  US8481564 Publication Date 7/9/2013
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Macrophage colony-stimulating factor 1 (CSF-1)
Name:Macrophage colony-stimulating factor 1 (CSF-1)
Synonyms:n/a
Type:Protein
Mol. Mass.:60631.84
Organism:Mus musculus (Mouse)
Description:P07141
Residue:552
Sequence:
MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQME
TSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLN
SCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSS
RDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELP
LRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGT
NWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFPKSTEDQKPVDIT
DRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQL
LLPKSHSWGIVLPLGELEGKRSTRDRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVE
QHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSHRDPQTLDSSVGRPEDSSL
TQDEDRQVELPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM97736
n/a
NameBDBM97736
Synonyms:US8481564, 13
TypeSmall molecule
Emp. Form.C22H25N7O3S
Mol. Mass.467.544
SMILESCS(=O)(=O)N=C1NCC(CN1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:30,(-7.73,-4.07,;-6.4,-3.3,;-6.4,-1.76,;-6.4,-4.84,;-5.07,-4.07,;-3.73,-3.3,;-2.4,-4.07,;-1.07,-3.3,;-1.07,-1.76,;-2.4,-.99,;-3.73,-1.76,;.27,-.99,;1.6,-1.76,;2.94,-.99,;2.94,.55,;4.27,1.32,;5.6,.55,;6.94,1.32,;6.37,-.78,;5.47,-2.03,;6.37,-3.27,;7.84,-2.8,;7.84,-1.26,;5.6,-4.61,;4.83,-5.94,;1.6,1.32,;.27,.55,;1.6,2.86,;2.94,3.63,;2.94,5.17,;1.6,5.94,;.27,5.17,;.27,3.63,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: