Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMacrophage colony-stimulating factor 1 (CSF-1)
LigandBDBM97739
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Competition Immunoassay
pH7.5±0
IC50 0.42± 0 nM
Citation Illig CRBallentine SKChen JDesJarlais RLMeegalla SKWall MWilson K Inhibitors of c-fms kinase US Patent  US8481564 Publication Date 7/9/2013
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Macrophage colony-stimulating factor 1 (CSF-1)
Name:Macrophage colony-stimulating factor 1 (CSF-1)
Synonyms:n/a
Type:Protein
Mol. Mass.:60631.84
Organism:Mus musculus (Mouse)
Description:P07141
Residue:552
Sequence:
MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQME
TSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLN
SCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSS
RDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELP
LRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGT
NWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFPKSTEDQKPVDIT
DRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQL
LLPKSHSWGIVLPLGELEGKRSTRDRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVE
QHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSHRDPQTLDSSVGRPEDSSL
TQDEDRQVELPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM97739
n/a
NameBDBM97739
Synonyms:US8481564, 54
TypeSmall organic molecule
Emp. Form.C26H30N8O
Mol. Mass.470.5694
SMILESCN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30,(-8.73,-1.92,;-7.39,-2.69,;-6.06,-1.93,;-4.73,-2.69,;-4.73,-4.23,;-6.06,-5,;-6.06,-6.54,;-7.39,-4.23,;-8.73,-5,;-8.73,-6.54,;-8.73,-8.08,;-3.39,-1.93,;-2.06,-2.69,;-.72,-1.93,;-.72,-.38,;.61,.38,;1.94,-.38,;1.94,-1.93,;3.28,.38,;3.28,1.93,;4.74,2.4,;5.65,1.15,;4.74,-.09,;5.51,3.73,;6.28,5.07,;-2.06,.38,;-3.39,-.38,;-2.06,1.93,;-.72,2.69,;-.72,4.23,;-2.06,5,;-3.15,6.09,;-.72,5.77,;-3.39,4.23,;-3.39,2.69,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: