| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
|---|
| Ligand | BDBM50198782 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Luciferase-Based Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 10.3±0.0 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Gong, X; Barrett, K; Cao, J; Gritzen, C; Noronha, G; Hood, JD; Mak, CC; McPherson, A; Pathak, VP; Renick, J; Soll, RM; Splittgerber, U; Wrasidlo, W; Zeng, B; Zhao, N; Dneprovskaia, E Benzotriazine inhibitors of kinases US Patent US8481536 Publication Date 7/9/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Yes |
|---|
| Name: | Tyrosine-protein kinase Yes |
|---|
| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60801.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07947 |
|---|
| Residue: | 543 |
|---|
| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
|
|
|
|---|
| BDBM50198782 |
|---|
| n/a |
|---|
| Name | BDBM50198782 |
|---|
| Synonyms: | ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) | 7-(2,6-dichlorophenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine | 7-(2,6-dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)-phenyl]-1,2,4-benzotriazin-3-amine | CHEMBL230686 | TG-100435 | US8481536, 367 | US8481536, 575 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25Cl2N5O |
|---|
| Mol. Mass. | 494.416 |
|---|
| SMILES | Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
