| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-derived growth factor receptor beta |
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| Ligand | BDBM50221556 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Luciferase-Based Assay |
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| IC50 | 2.8±0.0 nM |
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| Citation |  Gong, X; Barrett, K; Cao, J; Gritzen, C; Noronha, G; Hood, JD; Mak, CC; McPherson, A; Pathak, VP; Renick, J; Soll, RM; Splittgerber, U; Wrasidlo, W; Zeng, B; Zhao, N; Dneprovskaia, E Benzotriazine inhibitors of kinases US Patent US8481536 Publication Date 7/9/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-derived growth factor receptor beta |
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| Name: | Platelet-derived growth factor receptor beta |
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| Synonyms: | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF Receptor Substrate | PDGF-R-beta | PDGFR | PDGFR substrate | PDGFR-1 | PDGFR1 | PDGFRB | PDGFRbeta | PGFRB_HUMAN | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor 1 | Platelet-derived growth factor receptor beta | Platelet-derived growth factor receptor beta (PDGFR-beta) | Platelet-derived growth factor receptor beta (PDGFRB) | Platelet-derived growth factor receptor beta (PDGFRbeta) | VHL/PDGFRB |
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| Type: | Enzyme |
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| Mol. Mass.: | 123922.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09619 |
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| Residue: | 1106 |
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| Sequence: | MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPV
VWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFV
PDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFS
GIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGN
EVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDH
QDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDS
SAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL
ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNV
TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILA
LVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL
VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGP
HLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNAL
PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVP
SAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV
KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG
GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER
LLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND
YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQV
EPEPELEQLPDSGCPAPRAEAEDSFL
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| BDBM50221556 |
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| n/a |
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| Name | BDBM50221556 |
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| Synonyms: | 4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol | 7-(2-chloro-5-hydroxyphenyl)-5-methyl-N-[4-(piperidin-4-ylsulfonyl)phenyl]-1,2,4-benzotriazin-3-amine | CHEMBL250625 | US8481536, 536 | US8481536, 617 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24ClN5O3S |
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| Mol. Mass. | 510.008 |
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| SMILES | Cc1cc(cc2nnc(Nc3ccc(cc3)S(=O)(=O)C3CCNCC3)nc12)-c1cc(O)ccc1Cl |
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| Structure | 
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