| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM98036 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Assay |
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| pH | 7.4±0 |
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| IC50 | 5.9e+2±n/a nM |
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| Citation |  Austen, M; Black, P; Blackaby, W; Danilewicz, J; Linney, I; Schreiter, K; Schneider, M Thienopyrimidines for pharmaceutical compositions US Patent US8486953 Publication Date 7/16/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 51342.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BUB5 |
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| Residue: | 465 |
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| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
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| BDBM98036 |
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| n/a |
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| Name | BDBM98036 |
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| Synonyms: | US8486953, 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18FN3O3S |
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| Mol. Mass. | 375.417 |
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| SMILES | COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C |
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| Structure | 
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