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TargetGlutaminyl-peptide cyclotransferase
LigandBDBM98187
Substrate/Competitorn/a
Meas. Tech.Spectrophotometic Assay
Ki 12.5±n/a nM
IC50 160±n/a nM
Citation Heiser, URamsbeck, DSommer, RMeyer, AHoffmann, TBoehme, LDemuth, H Inhibitors US Patent US8486940 Publication Date 7/16/2013
More Info.:Get all data from this article,  Assay Method
 
Glutaminyl-peptide cyclotransferase
Name:Glutaminyl-peptide cyclotransferase
Synonyms:Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:Enzyme
Mol. Mass.:40877.05
Organism:Homo sapiens (Human)
Description:Q16769
Residue:361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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  Blast E-value cutoff:
BDBM98187
n/a
NameBDBM98187
Synonyms:US8486940, 89 | US9650362, 89
TypeSmall organic molecule
Emp. Form.C26H25N5O2
Mol. Mass.439.509
SMILESO=C1OC[C@@H](N1c1ccc2nc[nH]c2c1)c1ccc(cc1)N1CCN(CC1)c1ccccc1 |r|
Structure
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