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TargetActivin receptor type-1B
LigandBDBM280345
Substrate/Competitorn/a
Meas. Tech.In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases
IC50 30.4±n/a nM
Citation Rai, RChakravarty, SPujala, BShinde, BUNayak, AKChaklan, NAgarwal, AKRamachandran, SAPham, SM Compounds and methods of use US Patent US10030004 Publication Date 7/24/2018
More Info.:Get all data from this article,  Assay Method
 
Activin receptor type-1B
Name:Activin receptor type-1B
Synonyms:ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
Type:PROTEIN
Mol. Mass.:56810.99
Organism:Homo sapiens (Human)
Description:ChEMBL_587064
Residue:505
Sequence:
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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  Blast E-value cutoff:
BDBM280345
n/a
NameBDBM280345
Synonyms:(S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)pyrimidine-5-carboxamide | US10030004, Compound 12a | US10501436, Compound 12a | US11053216, Compound 12a | US11702401, Compound 12a
TypeSmall organic molecule
Emp. Form.C22H23ClFN5O2
Mol. Mass.443.902
SMILESC[C@H](O)CNC(=O)c1cncnc1Nc1cc(ncc1C(C)C)-c1cc(Cl)ccc1F |r|
Structure
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