| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1B |
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| Ligand | BDBM280357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases |
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| IC50 | 230±n/a nM |
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| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10030004 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-1B |
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| Name: | Activin receptor type-1B |
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| Synonyms: | ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56810.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_587064 |
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| Residue: | 505 |
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| Sequence: | MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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| BDBM280357 |
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| n/a |
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| Name | BDBM280357 |
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| Synonyms: | 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-pyridyl]amino]-N-[(1S)-1-(hydroxymethyl)propyl]pyridine-3-carboxamide | US10030004, Compound 24a | US10501436, Compound 24a | US11053216, Compound 24a | US11702401, Compound 24a |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24ClFN4O2 |
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| Mol. Mass. | 454.924 |
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| SMILES | CC[C@@H](CO)NC(=O)c1cnccc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F |r| |
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| Structure | 
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