| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
|---|
| Ligand | BDBM280424 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro M4 &M2 Functional Assay |
|---|
| EC50 | 20.0±n/a nM |
|---|
| Citation |  Livermore, D; White, K; Congreve, M; Brown, G; O Brien, M Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists US Patent US10030012 Publication Date 7/24/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M4 |
|---|
| Name: | Muscarinic acetylcholine receptor M4 |
|---|
| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 53079.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
|---|
| Residue: | 479 |
|---|
| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
|
|
|
|---|
| BDBM280424 |
|---|
| n/a |
|---|
| Name | BDBM280424 |
|---|
| Synonyms: | US10030012, Example 54 | ethyl 4-(4-{2-[(3- methyl-1,2- oxazol-5- yl)methoxy] pyridin-3- yl}piperidin-1- yl)azepane-1- carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H34N4O4 |
|---|
| Mol. Mass. | 442.5512 |
|---|
| SMILES | CCOC(=O)N1CCCC(CC1)N1CCC(CC1)c1cccnc1OCc1cc(C)no1 |
|---|
| Structure | 
|
|---|
Search and Browse
