| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM280454 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro M4 &M2 Functional Assay |
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| EC50 | 26.0±n/a nM |
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| Citation |  Livermore, D; White, K; Congreve, M; Brown, G; O Brien, M Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists US Patent US10030012 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 53079.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
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| Residue: | 479 |
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| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM280454 |
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| n/a |
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| Name | BDBM280454 |
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| Synonyms: | US10030012, Example 85 | ethyl (4S)-4-[4- (2-methoxy- pyridin- 3-yl)piperidin-1- yl]azepane-1- carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H31N3O3 |
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| Mol. Mass. | 361.4784 |
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| SMILES | CCOC(=O)N1CCC[C@@H](CC1)N1CCC(CC1)c1cccnc1OC |r| |
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| Structure | 
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