| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 |
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| Ligand | BDBM100350 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 3.2±0.0 nM |
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| Kd | 5.1±0 nM |
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| Citation |  Bauer, SM; Jia, ZJ; Mehrotra, M; Song, Y; Xu, Q; Huang, W; Venkataramani, C; Rose, JW; Pandey, A Inhibitors of protein kinases US Patent US8501944 Publication Date 8/6/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 |
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| Name: | Tyrosine-protein kinase JAK2 |
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| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) |
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| Type: | Protein |
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| Mol. Mass.: | 130684.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674 |
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| Residue: | 1132 |
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| Sequence: | MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
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| BDBM100350 |
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| n/a |
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| Name | BDBM100350 |
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| Synonyms: | US10533001, Example 99 | US11414410, Example 99 | US8501944, 372 | US8501944, 375 | US9868729, Example 99 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N7O3S |
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| Mol. Mass. | 431.512 |
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| SMILES | CS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1 |
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| Structure | 
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