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TargetMonoglyceride Lipase (MGL)
LigandBDBM280507
Substrate/Competitorn/a
Meas. Tech.In Vitro Competitive Activity-Based Protein Profiling
IC50<100±n/a nM
Citation Cisar JSGrice CAJones TKWeber ODBuzard DJShaghafi MB Spirocycle compounds and methods of making and using same US Patent  US10030020 Publication Date 7/24/2018
More Info.:Get all data from this article,  Assay Method
 
Monoglyceride Lipase (MGL)
Name:Monoglyceride Lipase (MGL)
Synonyms:MAG lipase | Monoacylglycerol lipase
Type:Hydrolase
Mol. Mass.:33391.67
Organism:Mus musculus (mouse)
Description:Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
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  Blast E-value cutoff:
BDBM280507
n/a
NameBDBM280507
Synonyms:US10030020, Example 52
TypeSmall organic molecule
Emp. Form.C30H38F9N3O3
Mol. Mass.659.6266
SMILESCC1(C)CC2(CN1Cc1ccc(cc1N1CCC3(C1)CCOCC3)C(F)(F)F)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F
Structure
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