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TargetMonoglyceride lipase
LigandBDBM280574
Substrate/Competitorn/a
Meas. Tech.In Vitro Competitive Activity-Based Protein Profiling (Human)
Temperature298.15±n/a K
IC50<100±n/a nM
Commentsextracted
Citation Cisar, JSGrice, CAJones, TKWeber, ODBuzard, DJShaghafi, MB Spirocycle compounds and methods of making and using same US Patent US10030020 Publication Date 7/24/2018
More Info.:Get all data from this article,  Assay Method
 
Monoglyceride lipase
Name:Monoglyceride lipase
Synonyms:HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:Hydrolase
Mol. Mass.:33264.56
Organism:Homo sapiens (Human)
Description:Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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  Blast E-value cutoff:
BDBM280574
n/a
NameBDBM280574
Synonyms:BDBM280666 | US10030020, Example 119 | US10781211, Example 119
TypeSmall organic molecule
Emp. Form.C26H30F9N3O4
Mol. Mass.619.5197
SMILESOC(=O)C1CCN(CC1)c1cc(ccc1CN1CCC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Structure
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