| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane prolyl 4-hydroxylase |
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| Ligand | BDBM3527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibition Assay |
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| pH | 7.5±0 |
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| Temperature | 298.15±0 K |
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| IC50 | 1.8e+2±n/a nM |
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| Citation |  Thede, K; Flamme, I; Oehme, F; Ergüden, J; Stoll, F; Schuhmacher, J; Wild, H; Kolkhof, P; Beck, H; Akbaba, M; Jeske, M Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors US Patent US8524699 Publication Date 9/3/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Transmembrane prolyl 4-hydroxylase |
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| Name: | Transmembrane prolyl 4-hydroxylase |
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| Synonyms: | Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56654.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NXG6 |
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| Residue: | 502 |
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| Sequence: | MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
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| BDBM3527 |
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| n/a |
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| Name | BDBM3527 |
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| Synonyms: | US8524699, 18 |
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| Type | n/a |
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| Emp. Form. | C16H16N6O2 |
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| Mol. Mass. | 324.3372 |
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| SMILES | O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-c1cccnc1 |
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| Structure | 
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