Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSerine/threonine-protein kinase PAK 4
LigandBDBM101546
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
Ki 1.6±n/a nM
EC50<3.9±0.0 nM
Citation Zhang, JGuo, CBouzida, DDong, LLi, HMarakovits, JTYang, AHong, Y Pyrrolopyrazoles, potent kinase inhibitors US Patent US8530652 Publication Date 9/10/2013
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PAK 4
Name:Serine/threonine-protein kinase PAK 4
Synonyms:KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:Protein
Mol. Mass.:64098.01
Organism:Homo sapiens (Human)
Description:O96013
Residue:591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM101546
n/a
NameBDBM101546
Synonyms:US8530494, 211 | US8530652, 125 | US8530652, 73
TypeSmall organic molecule
Emp. Form.C25H29N7O2S
Mol. Mass.491.608
SMILESCN(C)C[C@@H](OC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)[nH]nc2C1(C)C)c1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: