| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine synthase |
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| Ligand | BDBM102425 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 2.1e+3±n/a nM |
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| Citation |  Zhang, W; Sviripa, V; Chen, X; Shi, J; Yu, T; Hamza, A; Ward, ND; Kril, LM; Vander Kooi, CW; Zhan, CG; Evers, BM; Watt, DS; Liu, C Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol8:796-803 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine synthase |
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| Name: | S-adenosylmethionine synthase |
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| Synonyms: | Chain A, S-adenosylmethionine Synthetase | MAT2A | METK_ECOSM | metK |
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| Type: | n/a |
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| Mol. Mass.: | 41940.55 |
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| Organism: | Escherichia coli |
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| Description: | B1LDF1 |
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| Residue: | 384 |
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| Sequence: | MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTS
AWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQ
GLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVG
IDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDC
GLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVS
YAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGH
FGREHFPWEKTDKAQLLRDAAGLK
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| BDBM102425 |
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| n/a |
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| Name | BDBM102425 |
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| Synonyms: | FIDAS-5 | Fluorinated N,N-Dialkylaminostilbenes 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13ClFN |
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| Mol. Mass. | 261.722 |
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| SMILES | CNc1ccc(\C=C\c2c(F)cccc2Cl)cc1 |
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| Structure | 
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