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TargetFibroblast growth factor receptor 3
LigandBDBM102536
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50 11±0.0 nM
Citation Furet, PGraus Porta, DGuagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent US8536175 Publication Date 9/17/2013
More Info.:Get all data from this article,  Assay Method
 
Fibroblast growth factor receptor 3
Name:Fibroblast growth factor receptor 3
Synonyms:CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:Protein
Mol. Mass.:87699.57
Organism:Homo sapiens (Human)
Description:P22607
Residue:806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
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  Blast E-value cutoff:
BDBM102536
n/a
NameBDBM102536
Synonyms:US8536175, 135
TypeSmall organic molecule
Emp. Form.C25H24F2N6O4
Mol. Mass.510.4927
SMILESCOc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCOCC3)[nH]2)c2nccnc12 |(8.07,3.99,;8.85,2.66,;8.08,1.32,;8.85,-.01,;8.08,-1.34,;8.85,-2.68,;10.39,-2.68,;6.54,-1.34,;5.77,-2.68,;5.77,-.01,;6.54,1.32,;5.77,2.66,;4.23,-.01,;3.46,1.32,;1.92,1.32,;1.15,-.01,;-.39,-.01,;-1.16,1.32,;-1.16,-1.34,;-2.7,-1.34,;-3.61,-.1,;-5.07,-.57,;-5.07,-2.11,;-6.41,-2.88,;-7.74,-2.11,;-7.74,-.57,;-9.08,.2,;-10.41,-.57,;-10.41,-2.11,;-9.08,-2.88,;-3.61,-2.59,;1.92,-1.34,;1.15,-2.68,;1.92,-4.01,;3.46,-4.01,;4.23,-2.68,;3.46,-1.34,)|
Structure
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