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TargetFibroblast growth factor receptor 3
LigandBDBM102542
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50 11±0.0 nM
Citation Furet, PGraus Porta, DGuagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent US8536175 Publication Date 9/17/2013
More Info.:Get all data from this article,  Assay Method
 
Fibroblast growth factor receptor 3
Name:Fibroblast growth factor receptor 3
Synonyms:CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:Protein
Mol. Mass.:87699.57
Organism:Homo sapiens (Human)
Description:P22607
Residue:806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
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  Blast E-value cutoff:
BDBM102542
n/a
NameBDBM102542
Synonyms:US8536175, 153
TypeSmall organic molecule
Emp. Form.C23H22ClFN6O3
Mol. Mass.484.911
SMILESCOc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.42,4,;8.19,2.67,;7.42,1.33,;8.19,,;7.42,-1.33,;8.19,-2.67,;9.73,-2.67,;5.88,-1.33,;5.11,-2.67,;5.11,,;5.88,1.33,;5.11,2.67,;3.57,,;2.8,1.33,;1.26,1.33,;.49,,;-1.05,,;-1.82,1.33,;-1.82,-1.33,;-3.36,-1.33,;-4.26,-.09,;-5.73,-.56,;-5.73,-2.1,;-7.06,-2.87,;-8.4,-2.1,;-9.73,-2.87,;-8.4,-.56,;-4.26,-2.58,;1.26,-1.33,;.49,-2.67,;1.26,-4,;2.8,-4,;3.57,-2.67,;2.8,-1.33,)|
Structure
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