| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytoplasmic tyrosine-protein kinase BMX |
|---|
| Ligand | BDBM102620 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 8.0±0.0 nM |
|---|
| Citation |  Liu, F; Zhang, X; Weisberg, E; Chen, S; Hur, W; Wu, H; Zhao, Z; Wang, W; Mao, M; Cai, C; Simon, NI; Sanda, T; Wang, J; Look, AT; Griffin, JD; Balk, SP; Liu, Q; Gray, NS Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chem Biol8:1423-8 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Cytoplasmic tyrosine-protein kinase BMX |
|---|
| Name: | Cytoplasmic tyrosine-protein kinase BMX |
|---|
| Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 78030.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51813 |
|---|
| Residue: | 675 |
|---|
| Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
|
|
|
|---|
| BDBM102620 |
|---|
| n/a |
|---|
| Name | BDBM102620 |
|---|
| Synonyms: | BMX-IN-1 | N-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1, | US10000483, Compound I-14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H24N4O4S |
|---|
| Mol. Mass. | 524.59 |
|---|
| SMILES | Cc1ccc(cc1NC(=O)C=C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc(NS(C)(=O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
