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Reaction Details
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TargetTumor necrosis factor
LigandBDBM102666
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.0524±0.0 nM
IC50 61±0.0 nM
Citation Kozlowski, JAYu, WWong, MKKim, SHTong, LLavey, BJShankar, BBYang, DFeltz, RKosinski, AMZhou, GRizvi, RKDai, CFire, LGirijavallabhan, VLi, DPopovici-Muller, JRichard, JERosner, KESiddiqui, MAYang, L Compounds for the treatment of inflammatory disorders US Patent US8541572 Publication Date 9/24/2013
More Info.:Get all data from this article,  Assay Method
 
Tumor necrosis factor
Name:Tumor necrosis factor
Synonyms:Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:Enzyme
Mol. Mass.:25645.11
Organism:Homo sapiens (Human)
Description:P01375
Residue:233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM102666
n/a
NameBDBM102666
Synonyms:US8541572, 973
TypeSmall organic molecule
Emp. Form.C30H24N6O5
Mol. Mass.548.5488
SMILESCOc1ccc2CN(C[C@]3(NC(=O)NC3=O)C#Cc3ccc(cc3)-c3nc(ccc3O)-c3cnn(C)c3)C(=O)c2c1 |r|
Structure
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