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TargetTumor necrosis factor
LigandBDBM102669
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.0988±0.0 nM
IC50 39.75±0.0 nM
Citation Kozlowski, JAYu, WWong, MKKim, SHTong, LLavey, BJShankar, BBYang, DFeltz, RKosinski, AMZhou, GRizvi, RKDai, CFire, LGirijavallabhan, VLi, DPopovici-Muller, JRichard, JERosner, KESiddiqui, MAYang, L Compounds for the treatment of inflammatory disorders US Patent US8541572 Publication Date 9/24/2013
More Info.:Get all data from this article,  Assay Method
 
Tumor necrosis factor
Name:Tumor necrosis factor
Synonyms:Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:Enzyme
Mol. Mass.:25645.11
Organism:Homo sapiens (Human)
Description:P01375
Residue:233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM102669
n/a
NameBDBM102669
Synonyms:CHEMBL1288726 | US8541572, 976
TypeSmall organic molecule
Emp. Form.C32H31FN6O5
Mol. Mass.598.6241
SMILESCCN1CCN(CC1)c1ccc(O)c(n1)-c1ccc(cc1F)C#C[C@]1(CN2Cc3ccc(OC)cc3C2=O)NC(=O)NC1=O |r|
Structure
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