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TargetTumor necrosis factor
LigandBDBM102681
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.115±0.0 nM
IC50 55.9±0.0 nM
Citation Kozlowski JAYu WWong MKKim SHTong LLavey BJShankar BBYang DFeltz RKosinski AMZhou GRizvi RKDai CFire LGirijavallabhan VLi DPopovici-Muller JRichard JERosner KESiddiqui MAYang L Compounds for the treatment of inflammatory disorders US Patent  US8541572 Publication Date 9/24/2013
More Info.:Get all data from this article,  Assay Method
 
Tumor necrosis factor
Name:Tumor necrosis factor
Synonyms:Cachectin | TNF | TNF-a | TNFA | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNF╬▒) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:Enzyme
Mol. Mass.:25645.11
Organism:Homo sapiens (Human)
Description:P01375
Residue:233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM102681
n/a
NameBDBM102681
Synonyms:US8541572, 988
TypeSmall organic molecule
Emp. Form.C33H28N6O6
Mol. Mass.604.612
SMILESCCC(=O)Oc1ccc(nc1-c1ccc(cc1)C#C[C@]1(CN2Cc3ccc(OC)cc3C2=O)NC(=O)NC1=O)-c1cnn(C)c1 |r|
Structure
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