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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Guanylate cyclase soluble subunit alpha-1 | ||
| Ligand | BDBM280851 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | sGC Binding Assay | ||
| pH | 7.4±n/a | ||
| Ki | 0.105±n/a nM | ||
| Comments | extracted | ||
| Citation |  Berger, R; Chen, Y; Li, G; Garfunkle, J; Li, H; Miao, S; Raghavan, S; Smith, CJ; Stelmach, J; Whitehead, A; Zhang, R; Zhang, Y; Fu, J; Ji, G; Jiang, F Soluble guanylate cyclase stimulators US Patent US10030027 Publication Date 7/24/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Guanylate cyclase soluble subunit alpha-1 | |||
| Name: | Guanylate cyclase soluble subunit alpha-1 | ||
| Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 77457.21 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q02108 | ||
| Residue: | 690 | ||
| Sequence: |
| ||
| BDBM280851 | |||
| n/a | |||
| Name | BDBM280851 | ||
| Synonyms: | 3-{2-[4-amino-2-{6- chloro-1-[4- methylcyclohexylmethyl]- 1H-indazol-3-yl}-5- methyl-6-oxo-6,7- dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl]-1,3- oxazol-4-yl}-2,2- dimethylpropanoic acid | US10030027, Example 132AA | US10030027, Example 132AB | US10428076, Example 132AB | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H34ClN7O4 | ||
| Mol. Mass. | 592.088 | ||
| SMILES | CC1CCC(Cn2nc(-c3nc4NC(=O)C(C)(c5nc(CC(C)(C)C(O)=O)co5)c4c(N)n3)c3ccc(Cl)cc23)CC1 |(-1.39,-7.53,;-2.48,-6.44,;-3.97,-6.84,;-5.06,-5.75,;-4.66,-4.26,;-5.75,-3.17,;-5.35,-1.69,;-3.89,-1.21,;-3.89,.33,;-2.55,1.1,;-1.22,.33,;.11,1.1,;1.58,.62,;2.48,1.87,;4.02,1.87,;1.58,3.12,;.81,4.45,;2.91,3.89,;4.38,3.41,;5.28,4.66,;6.82,4.66,;7.59,5.99,;7.59,7.53,;6.26,6.76,;9.13,5.99,;9.9,7.32,;9.9,4.66,;4.38,5.9,;2.91,5.43,;.11,2.64,;-1.22,3.41,;-1.22,4.95,;-2.55,2.64,;-5.35,.81,;-5.98,2.21,;-7.51,2.37,;-8.41,1.13,;-9.9,1.53,;-7.79,-.28,;-6.26,-.44,;-3.17,-3.86,;-2.08,-4.95,)| | ||
| Structure | 
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