Reaction Details |
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Target | Guanylate cyclase soluble subunit alpha-1 |
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Ligand | BDBM280871 |
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Substrate/Competitor | n/a |
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Meas. Tech. | sGC Binding Assay |
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pH | 7.4±n/a |
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Ki | 0.075±n/a nM |
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Comments | extracted |
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Citation | Berger, R; Chen, Y; Li, G; Garfunkle, J; Li, H; Miao, S; Raghavan, S; Smith, CJ; Stelmach, J; Whitehead, A; Zhang, R; Zhang, Y; Fu, J; Ji, G; Jiang, F Soluble guanylate cyclase stimulators US Patent US10030027 Publication Date 7/24/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Guanylate cyclase soluble subunit alpha-1 |
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Name: | Guanylate cyclase soluble subunit alpha-1 |
Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
Type: | Enzyme |
Mol. Mass.: | 77457.21 |
Organism: | Homo sapiens (Human) |
Description: | Q02108 |
Residue: | 690 |
Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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BDBM280871 |
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n/a |
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Name | BDBM280871 |
Synonyms: | 4-(2-{4-amino-2- [1-(2-fluorobenzyl)- 1H-pyrazolo[3,4-b] pyridin-3-yl]-5- methyl-6-oxo-6,7- dihydro-5H-pyrrolo [2,3-d]pyrimidin- 5-yl}-1,3-thiazol-4- yl)benzoic acid | US10030027, Example 147A | US10428076, Example 147A |
Type | Small organic molecule |
Emp. Form. | C30H21FN8O3S |
Mol. Mass. | 592.603 |
SMILES | CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1nc(cs1)-c1ccc(cc1)C(O)=O |
Structure |
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