| Reaction Details |
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 | Report a problem with these data |
| Target | Guanylate cyclase soluble subunit alpha-1 |
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| Ligand | BDBM280939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | sGC Binding Assay |
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| pH | 7.4±n/a |
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| Ki | 0.067±n/a nM |
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| Comments | extracted |
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| Citation |  Berger, R; Chen, Y; Li, G; Garfunkle, J; Li, H; Miao, S; Raghavan, S; Smith, CJ; Stelmach, J; Whitehead, A; Zhang, R; Zhang, Y; Fu, J; Ji, G; Jiang, F Soluble guanylate cyclase stimulators US Patent US10030027 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanylate cyclase soluble subunit alpha-1 |
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| Name: | Guanylate cyclase soluble subunit alpha-1 |
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| Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 77457.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02108 |
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| Residue: | 690 |
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| Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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| BDBM280939 |
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| n/a |
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| Name | BDBM280939 |
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| Synonyms: | (2E)-3-(4-{4- amino-2-[1-(2- fluorobenzyl)-1H- pyrazolo[3,4-b] pyridin-3-yl]-5- methyl-6-oxo- 6,7-dihydro-5H- pyrrolo[2,3-d] pyrimidin-5-yl} phenyl)prop-2- enoic acid | US10030027, Example 217A | US10428076, Example 217A |
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| Type | Small organic molecule |
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| Emp. Form. | C29H22FN7O3 |
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| Mol. Mass. | 535.5285 |
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| SMILES | CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)c1ccc(\C=C\C(O)=O)cc1 |
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| Structure | 
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