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TargetMitogen-activated protein kinase 1
LigandBDBM103294
Substrate/Competitorn/a
Meas. Tech.IMAP Assay
IC50 8.2±0.0 nM
Citation Cooper ABDeng YShipps, Jr. GWShih NZhu HYSun RKelly JMDoll RJNan YWang TDesai JAWang JJDong YMadison VSXiao LHruza AWSiddiqui MASamatar AAPaliwal STsui HCelebi AAWu YBoga SBAlhassan AGao XZhu LPatel M Compounds that are ERK inhibitors US Patent  US8546404 Publication Date 10/1/2013
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | Mitogen-activated protein kinase 2 | p42 | p42-MAPK
Type:Protein
Mol. Mass.:41278.65
Organism:Mus musculus (Mouse)
Description:P63085
Residue:358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM103294
n/a
NameBDBM103294
Synonyms:US8546404, 487
TypeSmall organic molecule
Emp. Form.C36H36N8O3
Mol. Mass.628.7228
SMILESCO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r,c:12|
Structure
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