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TargetMitogen-activated protein kinase 1
LigandBDBM103298
Substrate/Competitorn/a
Meas. Tech.IMAP Assay
IC50 20±0.0 nM
Citation Cooper, ABDeng, YShipps, Jr., GWShih, NZhu, HYSun, RKelly, JMDoll, RJNan, YWang, TDesai, JAWang, JJDong, YMadison, VSXiao, LHruza, AWSiddiqui, MASamatar, AAPaliwal, STsui, HCelebi, AAWu, YBoga, SBAlhassan, AGao, XZhu, LPatel, M Compounds that are ERK inhibitors US Patent US8546404 Publication Date 10/1/2013
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK
Type:Protein
Mol. Mass.:41278.65
Organism:Mus musculus (Mouse)
Description:P63085
Residue:358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM103298
n/a
NameBDBM103298
Synonyms:US8546404, 825
TypeSmall organic molecule
Emp. Form.C36H33F2N7O3
Mol. Mass.649.6891
SMILESCO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2F)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 |r,c:12|
Structure
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