| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
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| Ligand | BDBM34529 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IMAP Assay |
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| IC50 | 9.1±0.0 nM |
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| Citation |  Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Compounds that are ERK inhibitors US Patent US8546404 Publication Date 10/1/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 |
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| Name: | Mitogen-activated protein kinase 1 |
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| Synonyms: | ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK |
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| Type: | Protein |
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| Mol. Mass.: | 41278.65 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P63085 |
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| Residue: | 358 |
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| Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM34529 |
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| n/a |
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| Name | BDBM34529 |
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| Synonyms: | US8546404, 479 | US8546404, 489 |
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| Type | n/a |
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| Emp. Form. | C36H36FN7O3 |
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| Mol. Mass. | 633.7145 |
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| SMILES | CO[C@]1(CCN(CC(=O)N2CCC(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 |r| |
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| Structure | 
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