Reaction Details |
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Target | Tyrosine-protein kinase ZAP-70 |
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Ligand | BDBM103517 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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IC50 | 44±n/a nM |
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Citation | Okram, B; Uno, T; Ding, Q; Liu, Y; Jin, Y; Jin, Q; Wu, X; Che, J; Yan, SF; Hao, X Compounds and compositions as kinase inhibitors US Patent US8546370 Publication Date 10/1/2013 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ZAP-70 |
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Name: | Tyrosine-protein kinase ZAP-70 |
Synonyms: | 70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa |
Type: | Enzyme |
Mol. Mass.: | 69881.61 |
Organism: | Homo sapiens (Human) |
Description: | ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column. |
Residue: | 619 |
Sequence: | MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
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BDBM103517 |
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n/a |
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Name | BDBM103517 |
Synonyms: | US8546370, 130 |
Type | Small organic molecule |
Emp. Form. | C28H32N6O2 |
Mol. Mass. | 484.5927 |
SMILES | CC(C)Cn1cc(cn1)-c1cc2cc[nH]c(=O)c2c(Nc2ccc(cc2)C2CCN(CC2)C(C)=O)n1 |
Structure |
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