| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ZAP-70 |
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| Ligand | BDBM103527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 79±n/a nM |
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| Citation |  Okram, B; Uno, T; Ding, Q; Liu, Y; Jin, Y; Jin, Q; Wu, X; Che, J; Yan, SF; Hao, X Compounds and compositions as kinase inhibitors US Patent US8546370 Publication Date 10/1/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ZAP-70 |
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| Name: | Tyrosine-protein kinase ZAP-70 |
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| Synonyms: | 70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa |
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| Type: | Enzyme |
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| Mol. Mass.: | 69881.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column. |
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| Residue: | 619 |
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| Sequence: | MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
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| BDBM103527 |
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| n/a |
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| Name | BDBM103527 |
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| Synonyms: | US8546370, 589 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28N6O |
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| Mol. Mass. | 452.5508 |
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| SMILES | Cc1cc(Nc2nc(cc3cc[nH]c(=O)c23)-c2cncnc2)ccc1C1CCN(CC1)C1CC1 |
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| Structure | 
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