Reaction Details |
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Target | Serine/threonine-protein kinase B-raf [V600E] |
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Ligand | BDBM103674 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Raf/Mek Amplified Luminescence Proximity Homogeneous Assay |
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pH | 7.5±0 |
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IC50 | 0.23±n/a nM |
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Citation | Costales, AQ; Huang, S; Jin, JX; Liu, Z; Pecchi, S; Poon, D; Tellew, J Compounds and compositions as protein kinase inhibitors US Patent US8563553 Publication Date 10/22/2013 |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Serine/threonine-protein kinase B-raf [V600E] |
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Name: | Serine/threonine-protein kinase B-raf [V600E] |
Synonyms: | B-RAF V600E | B-Raf (V600E) | B-Raf Protein Kinase Mutant (V600E) | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF (V600E) | BRAF mutant V600E | BRAF1 | BRAF_HUMAN | P15056 | Protein mono-ADP-ribosyltransferase (PARP3) | RAF serine/threonine protein kinase (V600E) | RAFB1 | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf [V600E] | V-RAF murine sarcoma viral oncogene homologue B1 mutant (BRAF V600E) |
Type: | n/a |
Mol. Mass.: | 84474.98 |
Organism: | Homo sapiens (Human) |
Description: | P15056 V600E |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATE
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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BDBM103674 |
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n/a |
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Name | BDBM103674 |
Synonyms: | US8563553, 99 |
Type | Small organic molecule |
Emp. Form. | C21H21ClFN7O2S |
Mol. Mass. | 489.954 |
SMILES | CC1(CC1)c1nc(c([nH]1)-c1cc(F)cc(NS(C)(=O)=O)c1Cl)-c1ccnc(NCCC#N)n1 |
Structure |
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