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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf [V600E] | ||
| Ligand | BDBM103655 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Raf/Mek Amplified Luminescence Proximity Homogeneous Assay | ||
| pH | 7.5±0 | ||
| IC50 | 0.45±n/a nM | ||
| Citation |  Costales, AQ; Huang, S; Jin, JX; Liu, Z; Pecchi, S; Poon, D; Tellew, J Compounds and compositions as protein kinase inhibitors US Patent US8563553 Publication Date 10/22/2013 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Serine/threonine-protein kinase B-raf [V600E] | |||
| Name: | Serine/threonine-protein kinase B-raf [V600E] | ||
| Synonyms: | B-RAF V600E | B-Raf (V600E) | B-Raf Protein Kinase Mutant (V600E) | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF (V600E) | BRAF mutant V600E | BRAF1 | BRAF_HUMAN | P15056 | Protein mono-ADP-ribosyltransferase (PARP3) | RAF serine/threonine protein kinase (V600E) | RAFB1 | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf [V600E] | V-RAF murine sarcoma viral oncogene homologue B1 mutant (BRAF V600E) | ||
| Type: | n/a | ||
| Mol. Mass.: | 84474.98 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 V600E | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM103655 | |||
| n/a | |||
| Name | BDBM103655 | ||
| Synonyms: | US8563553, 80 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H29ClFN7O4S | ||
| Mol. Mass. | 566.048 | ||
| SMILES | CCCS(=O)(=O)Nc1ccc(F)c(-c2[nH]c(nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C2CC2)c1Cl |r,wU:25.26,(-5.86,4.43,;-4.77,3.35,;-3.28,3.74,;-2.2,2.66,;-1.11,3.74,;-3.28,1.57,;-1.11,1.57,;.38,1.96,;.78,3.45,;2.27,3.85,;3.36,2.76,;4.84,3.16,;2.96,1.27,;4.05,.19,;5.51,.66,;6.42,-.58,;5.51,-1.83,;4.05,-1.35,;2.71,-2.12,;2.71,-3.66,;1.38,-4.43,;.05,-3.66,;.05,-2.12,;-1.29,-1.35,;-2.62,-2.12,;-3.96,-1.35,;-3.96,.19,;-5.29,-2.12,;-6.62,-1.35,;-6.62,.19,;-7.96,-2.12,;-9.29,-1.35,;1.38,-1.35,;7.96,-.58,;9.29,-1.35,;9.29,.19,;1.47,.88,;1.07,-.61,)| | ||
| Structure | 
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