| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4C [1-973] |
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| Ligand | BDBM103842 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro Hydroxylation Assays for PHD2 (AlphaScreen) |
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| pH | 7.5±0 |
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| IC50 | >1.00e+5±n/a nM |
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| Citation |  Chowdhury, R; Candela-Lena, JI; Chan, MC; Greenald, DJ; Yeoh, KK; Tian, YM; McDonough, MA; Tumber, A; Rose, NR; Conejo-Garcia, A; Demetriades, M; Mathavan, S; Kawamura, A; Lee, MK; van Eeden, F; Pugh, CW; Ratcliffe, PJ; Schofield, CJ Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases. ACS Chem Biol8:1488-96 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Lysine-specific demethylase 4C [1-973] |
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| Name: | Lysine-specific demethylase 4C [1-973] |
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| Synonyms: | GASC1 | JHDM3C | JMJD2C | Jumonji domain-containing protein 2C (JMJD2C) | KDM4C | KDM4C_HUMAN | KIAA0780 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 110027.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H3R0[1-973] |
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| Residue: | 973 |
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| Sequence: | MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC
YDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLE
RKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYF
GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFL
RHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWID
YGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWL
QRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAV
KLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSI
SSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLE
PGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEV
LSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSS
NEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAK
CCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAV
AVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTC
AHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVM
AVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGS
NIAHMYQVEFEDG
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| BDBM103842 |
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| n/a |
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| Name | BDBM103842 |
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| Synonyms: | 4HQ derivative 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N2O4 |
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| Mol. Mass. | 260.2454 |
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| SMILES | Cc1nc(C(=O)NCC(O)=O)c(O)c2ccccc12 |
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| Structure | 
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