Reaction Details |
| Report a problem with these data |
Target | Lysine-specific demethylase 4E |
---|
Ligand | BDBM103845 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In vitro Hydroxylation Assays for PHD2 (AlphaScreen) |
---|
pH | 7.5±0 |
---|
IC50 | 9.9e+4±n/a nM |
---|
Citation | Chowdhury, R; Candela-Lena, JI; Chan, MC; Greenald, DJ; Yeoh, KK; Tian, YM; McDonough, MA; Tumber, A; Rose, NR; Conejo-Garcia, A; Demetriades, M; Mathavan, S; Kawamura, A; Lee, MK; van Eeden, F; Pugh, CW; Ratcliffe, PJ; Schofield, CJ Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases. ACS Chem Biol8:1488-96 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Lysine-specific demethylase 4E |
---|
Name: | Lysine-specific demethylase 4E |
Synonyms: | 2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E) |
Type: | Enzyme |
Mol. Mass.: | 56815.71 |
Organism: | Homo sapiens (Human) |
Description: | B2RXH2 |
Residue: | 506 |
Sequence: | MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
|
|
|
BDBM103845 |
---|
n/a |
---|
Name | BDBM103845 |
Synonyms: | 4HQ derivative 8 |
Type | Small organic molecule |
Emp. Form. | C19H24N2O4 |
Mol. Mass. | 344.4049 |
SMILES | CCCCCCCc1nc(C(=O)NCC(O)=O)c(O)c2ccccc12 |
Structure |
|