Reaction Details |
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Target | Lysine-specific demethylase 2A |
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Ligand | BDBM103842 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In vitro Hydroxylation Assays for PHD2 (AlphaScreen) |
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pH | 7.5±0 |
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IC50 | 1.00e+5±n/a nM |
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Citation | Chowdhury, R; Candela-Lena, JI; Chan, MC; Greenald, DJ; Yeoh, KK; Tian, YM; McDonough, MA; Tumber, A; Rose, NR; Conejo-Garcia, A; Demetriades, M; Mathavan, S; Kawamura, A; Lee, MK; van Eeden, F; Pugh, CW; Ratcliffe, PJ; Schofield, CJ Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases. ACS Chem Biol8:1488-96 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Lysine-specific demethylase 2A |
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Name: | Lysine-specific demethylase 2A |
Synonyms: | AA1-1162 | CXXC8 | F-box and leucine-rich repeat protein 11 | FBL11 | FBL7 | FBXL11 | Homo sapiens lysine demethylase 2A (KDM2A) | JHDM1A | KDM2A | KDM2A_HUMAN | KIAA1004 | Lysine-specific demethylase 2A | Lysine-specific demethylase 2A (KDM2A) | NM_012308 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 132809.04 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 1162 |
Sequence: | MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK
DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE
MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN
LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL
HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT
LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT
GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM
KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG
LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP
SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC
PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS
WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR
DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ
SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF
ISDLSINSLYCLSDEKLIQKIS
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BDBM103842 |
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n/a |
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Name | BDBM103842 |
Synonyms: | 4HQ derivative 4 |
Type | Small organic molecule |
Emp. Form. | C13H12N2O4 |
Mol. Mass. | 260.2454 |
SMILES | Cc1nc(C(=O)NCC(O)=O)c(O)c2ccccc12 |
Structure |
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