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TargetPeptidoglycan D,D-transpeptidase FtsI
LigandBDBM104099
Substrate/Competitorn/a
Meas. Tech.IC50 Assay
pH7.2±n/a
Temperature298.15±n/a K
IC50 1.96e+5± 2.8e+4 nM
Commentsextracted
Citation van Berkel, SSNettleship, JELeung, IKBrem, JChoi, HStuart, DIClaridge, TDMcDonough, MAOwens, RJRen, JSchofield, CJ Binding of (5S)-penicilloic acid to penicillin binding protein 3. ACS Chem Biol8:2112-6 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidoglycan D,D-transpeptidase FtsI
Name:Peptidoglycan D,D-transpeptidase FtsI
Synonyms:Penicillin binding protein 3 (PBP3)
Type:Protein
Mol. Mass.:62820.53
Organism:Pseudomonas aeruginosa
Description:A6VB91
Residue:579
Sequence:
MKLNHFQGALYPWRFCVIVGLLLAMVGAIVWRIVDLHVIDHDFLKGQGDARSVRHIAIPA
HRGLITDRNGEPLAVSTPVTTLWANPKELMAAKERWPQLAAALGQDTKLFADRIEQNAER
EFIYLVRGLTPEQGEGVISLKVPGVYSIEEFRRFYPAGEVVAHAVGFTDVDDRGREGIEL
AFDEWLAGVPGKRQVLKDRRGRVIKDVQVTKNAKPGKTLALSIDLRLQYLAHRELRNALV
ENGAKAGSLVIMDVKTGEILAMTNQPTYNPNNRRNLQPAAMRNRAMIDVFEPGSTVKPFS
MSAALASGRWKPSDIVDVYPGTLQIGRYTIRDVSRNSRQLDLTGILIKSSNVGISKIAFD
IGAESIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYGYGLSVTAIQLAH
AYAALANDGKSVPLSMTRVDRVPDGVQVISPEVASTVQGMLQQVVEAQGGVFRAQVPGYH
AAGKSGTARKVSVGTKGYRENAYRSLFAGFAPATDPRIAMVVVIDEPSKAGYFGGLVSAP
VFSKVMAGALRLMNVPPDNLPTATEQQQVNAAPAKGGRG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM104099
n/a
NameBDBM104099
Synonyms:(5R)-PA | (5R)-Penicilloic acid
TypeSmall organic molecule
Emp. Form.C23H31N5O8S
Mol. Mass.537.586
SMILESCCN1CCN(C(=O)N[C@H](C2CC=CC=C2)C(=O)N[C@@H]([C@@H]2N[C@@H](C(O)=O)C(C)(C)S2)C(O)=O)C(=O)C1=O |r,c:12,14|
Structure
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