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TargetGag-Pol polyprotein [484-582,I497V,V499I,E519D,G532V,I538V,R541K,D544E,Q553K,V566A,L573M]
LigandBDBM104102
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.376±0.168 nM
Citation Shen, YAltman, MDAli, ANalam, MNCao, HRana, TMSchiffer, CATidor, B Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol8:2433-41 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gag-Pol polyprotein [484-582,I497V,V499I,E519D,G532V,I538V,R541K,D544E,Q553K,V566A,L573M]
Name:Gag-Pol polyprotein [484-582,I497V,V499I,E519D,G532V,I538V,R541K,D544E,Q553K,V566A,L573M]
Synonyms:HIV-1 protease M1 | HIV-1 protease drug-resistant mutant 1 | POL_HV196 | gag-pol
Type:Protein
Mol. Mass.:10757.68
Organism:Human immunodeficiency virus
Description:Q9QBY3[484-582,I497V,V499I,E519D,G532V,I538V,R541K,D544E,Q553K,V566A,L573M]
Residue:99
Sequence:
PQITLWQRPIVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIVGIGGFVKVKQYE
QVLIEICGKKAIGTVLVGPTPANIIGRNMLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM104102
n/a
NameBDBM104102
Synonyms:(2S,3S)-2-(Acetylamino)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)[(2S)-2- methylbutyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-methyl-pentanamide (AG-23)
TypeSmall organic molecule
Emp. Form.C30H42N4O5S2
Mol. Mass.602.808
SMILESCC[C@H](C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)C(NC(C)=O)[C@@H](C)CC)S(=O)(=O)c1ccc2ncsc2c1 |r|
Structure
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