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TargetHIV-1 protease M3
LigandBDBM104102
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.048±0.022 nM
Citation Shen YAltman MDAli ANalam MNCao HRana TMSchiffer CATidor B Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol 8:2433-41 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HIV-1 protease M3
Name:HIV-1 protease M3
Synonyms:HIV-1 protease drug-resistant mutant 3
Type:Protein
Mol. Mass.:10819.77
Organism:Human immunodeficiency virus
Description:n/a
Residue:99
Sequence:
PQITLWQRPIVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
QVLIEICGKKVISTVLVGPTPVNVIGRNMMTQIGCTLNF
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BDBM104102
n/a
NameBDBM104102
Synonyms:(2S,3S)-2-(Acetylamino)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)[(2S)-2- methylbutyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-methyl-pentanamide (AG-23)
TypeSmall organic molecule
Emp. Form.C30H42N4O5S2
Mol. Mass.602.808
SMILESCC[C@H](C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)C(NC(C)=O)[C@@H](C)CC)S(=O)(=O)c1ccc2ncsc2c1 |r|
Structure
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