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TargetHIV-1 protease M4
LigandBDBM104107
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.144±0.115 nM
Citation Shen YAltman MDAli ANalam MNCao HRana TMSchiffer CATidor B Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol 8:2433-41 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HIV-1 protease M4
Name:HIV-1 protease M4
Synonyms:HIV-1 protease drug-resistant mutant 4
Type:Protein
Mol. Mass.:10771.71
Organism:Human immunodeficiency virus
Description:n/a
Residue:99
Sequence:
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGVGGFIKVKQYE
QVLIEICGKKVIGTVLVGPTPVNIIGRNMLTQIGCTLNF
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  Blast E-value cutoff:
BDBM104107
n/a
NameBDBM104107
Synonyms:(2S,3S)-2-(Acetylamino)-N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2- methylpropyl)amino]-1-(phenylmethyl)propyl]-3-methyl-pentanamide (AF-68)
TypeSmall organic molecule
Emp. Form.C29H43N3O6S
Mol. Mass.561.733
SMILESCC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN(CC(C)C)S(=O)(=O)c1ccc(OC)cc1 |r|
Structure
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