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TargetHIV-1 protease M4
LigandBDBM104109
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 5.887±2.755 nM
Citation Shen YAltman MDAli ANalam MNCao HRana TMSchiffer CATidor B Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol 8:2433-41 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HIV-1 protease M4
Name:HIV-1 protease M4
Synonyms:HIV-1 protease drug-resistant mutant 4
Type:Protein
Mol. Mass.:10771.71
Organism:Human immunodeficiency virus
Description:n/a
Residue:99
Sequence:
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGVGGFIKVKQYE
QVLIEICGKKVIGTVLVGPTPVNIIGRNMLTQIGCTLNF
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BDBM104109
n/a
NameBDBM104109
Synonyms:3-Hydroxy-N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](3-phenylpropyl)amino]- 1-(phenylmethyl)propyl]-benzamide (AF-78)
TypeSmall organic molecule
Emp. Form.C33H36N2O6S
Mol. Mass.588.714
SMILESCOc1ccc(cc1)S(=O)(=O)N(CCCc1ccccc1)C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(O)c1 |r|
Structure
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