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TargetHIV WT-B pol protein (wild-type clade B)
LigandBDBM104107
Substrate/Competitorn/a
Meas. Tech.Drug Susceptibility Assay
EC50 1.6±0.0 nM
Citation Shen YAltman MDAli ANalam MNCao HRana TMSchiffer CATidor B Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol 8:2433-41 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HIV WT-B pol protein (wild-type clade B)
Name:HIV WT-B pol protein (wild-type clade B)
Synonyms:WT-B
Type:Protein
Mol. Mass.:45584.13
Organism:Human immunodeficiency virus
Description:n/a
Residue:401
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMHLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNFPISPIETVPVKLKPGMDGPKV
KQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELN
KRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPG
IRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQNPDIVIYQYMDDLYVGSDLEIGQHRAKI
EELREHLLWGTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKL
NWASQIYAGIKVRQLCKLLRGAKALTEVIQLTEEAELELAE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM104107
n/a
NameBDBM104107
Synonyms:(2S,3S)-2-(Acetylamino)-N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2- methylpropyl)amino]-1-(phenylmethyl)propyl]-3-methyl-pentanamide (AF-68)
TypeSmall organic molecule
Emp. Form.C29H43N3O6S
Mol. Mass.561.733
SMILESCC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN(CC(C)C)S(=O)(=O)c1ccc(OC)cc1 |r|
Structure
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